The ICTALS conference (International Conference on Technology and Analysis of Seizures) gathers scientists and clinicians around one common goal: use quantitative methods to analyze seizures and better understand and treat the disorder. The 2022 edition of ICTALS, entitled “The tipping point” will inscribe itself into the long tradition of aiming at forecasting seizures. It will put emphasis on a deeper understanding of possible factors that may help attain this goal.