The APC Executive Committee is highly conscientious of the impact that the current COVID-19 pandemic has on travel and event restrictions. We strongly believe in mitigating the spread of the virus while still maintaining the ability to facilitate the exchange between experts, and positively impact the lives of patients with advanced prostate cancer. Therefore the APCCC 2022 is planned as a hybrid event. We will hold the conference as a face-to-face meeting, while providing the benefits of the conference in an online format. This opens opportunities for attendance to valuable experts from around the world, who may otherwise not be able to attend. Additionally, it provides us the flexibility to move to a completely virtual format, should a face-to-face meeting not be feasible.