Orthopaedic infections, including fracture-related infection (FRI), periprosthetic joint infection (PJI) and osteomyelitis, remain amongst the most challenging complications in orthopaedic and musculoskeletal trauma surgery. These infections have been convincingly shown to delay healing, worsen functional outcome and incur significant socio-economic costs. Although awareness of the clinical challenge of infection has increased in recent years, diagnostic and therapeutic options have remained unchanged. The 2024 ARI Orthopaedics conference will focus on the underlying biology of bone infection, from both the host and pathogen perspective. The clinical challenges, including antibiotic resistant, recurring infections will be discussed as well as the specific requirements of bone reconstruction after debridement of infected tissues. Some emerging concepts in the field of orthopaedic infection will also be introduced, including bacteriophage therapy and nanotechnology. These new topics will supplement the more established field of antimicrobial therapy, drug delivery and biofilm biology. We look forward to welcoming researchers and clinicians with an interest in basic microbiology, materials science, immunology, biomedical engineering as well as translational research to Davos in 2024.