Cellular senescence, a physiological mechanism that stops cell growth and reduces their metabolic activity in response to damage or stress factors such as aging, is now at the center of an innovative line of scientific research. This process, which plays a fundamental role in slowing the formation of tumors, is also responsible for the accumulation of senescent cells in the body that over time contributes to premature aging and the development of chronic inflammation, tissue dysfunction and age-related disorders, including cancer. Understanding and modulating senescence through targeted therapies is becoming one of the main challenges for contemporary medicine, with potential implications in terms of health and social and economic impact. This is the heart of the Scientific Forum “Senotherapeutics Revolution: Transforming Aging and Cancer Therapy”, promoted by the IBSA Foundation for Scientific Research in collaboration with the Institute of Oncology Research (IOR) and the Institute for Research in Biomedicine (IRB), the Institute Foundation of Molecular Oncology ETS (IFOM) and the Institute of Molecular Genetics (CNR-IGM), which will be held on June 30 at USI in Lugano and is part of a context of growing attention towards senescence as a possible therapeutic target to combat aging-related diseases and improve the effectiveness of cancer therapies. The Forum will conclude with a special conference by Valter Longo, Edna M. Jones Professor of Gerontology and Biological Sciences and Director of the Longevity Institute at the University of Southern California, who will explore the benefits of the Fasting Mimicking Diet (FMD). Diets (FMDs) on health and longevity.