World Chagas Disease Day, observed annually on April, brings global attention to Chagas disease, a neglected tropical disease that disproportionately affects the poor and marginalized, often those without access to healthcare or a political voice. First recognized in 2020, the day aims to raise awareness, promote early detection and treatment, and advocate for the interruption of its transmission, emphasizing the disease’s slow, often asymptomatic progression which, without treatment, can lead to severe complications and even death.